Modalert is a non-addictive synthetic non-amphetamine stimulant. The drug promotes wakefulness and alertness and is much safer than Adderall. According to Harvard and Oxford University researchers, it is the world’s first safe “smart drug.”
In this beginner’s guide, we detail everything you need to know about Modalert. Including, how the drug works, what it used for, side effects, and contraindications. We’ll also go over how Modalert stacks up against other stimulants.
What Is Modalert?
Modalert is the generic version of Modafinil (2-[(diphenylmethyl) sulfinyl] acetamide), an active metabolite of the prodrug, Adrafinil.
The discovery of Adrafinil’s wake-promoting properties dates back to the mid-70s and was purely accidental. Two French chemists working for a drug company found it while looking for analgesics.
In vivo testing of Adrafinil revealed that the drug had psychostimulant-like qualities, and promoted wakefulness and alertness. It did so without increasing heart rate or blood pressure, which are two common issues with traditional stimulants.
Other Brand Names For Modafinil
Other brand names under which Modafinil is sold worldwide include the following:
| Alertec | Forcilin | Modasomil | Movigil | Vigia | Wakelert |
| Alertex | Intensit | Modvigil | Provigil | Vigicer | Zalux |
| Altasomil | Mentix | Modiodal | Resotyl | Vigil | |
| Aspendos | Modanil | Modiwake | Stavigile | Vigimax |
How Modalert Works
Modalert stimulates the central nervous system (CNS). The central nervous system is a highly complex, multi-component organic communication network that consists of the brain, spinal cord, and neurons (or nerve cells). It controls most functions of the body and mind.
Specifically, modafinil acts on specific areas of the brain. These include the anterior and lateral regions of the hypothalamus.
The drug blocks 50 percent of dopamine transporters (DATs) in the brain. It also modifies the actions of noradrenaline transporters (NET). In so doing, Modalert increases the amount of those hormones (dopamine, histamine, orexin, and norepinephrine) in the brain.
Activatingorexin neurons increases dopamine and norepinephrine. High levels of dopamine in the brain boost focus, concentration, and alertness. Norepinephrine is important for attentiveness. An increase in histamines activates the histaminergic system which may promote waking.
Modafinil is, however, distinct from other amphetamines, in that it does not cause addiction or cardiovascular issues.
Main Benefits of Modalert
Modalert is primarily prescribed to treat disorders of sleep and wakefulness. Those conditions include the following:
Narcolepsy
Narcolepsy is a rare, chronic neurological disorder caused by a lack of hypocretin (orexin), a sleep-regulating brain chemical. The disease affects approximately 3 million worldwide and appears most common in Japan. Narcolepsy has no cure, and Modafinil is currently the drug of choice for the treatment.
Hypersomnia
Hypersomnia is a sleep disorder characterized by excessive daytime sleep or sleepiness. The condition is rarer than narcolepsy and affects 4 to 6 percent of the world’s population. It is a life-long disorder and has a higher prevalence in men.
Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS) is the most common type of sleep disorder and is also is more common in men than in women. The disease occurs when the airway is blocked to differing degrees, during sleep.
People with OSAHS experience excessive daytime sleepiness as well as headaches, irritability, night sweats, attention deficit, memory loss, decreased libido, and depression. Modafinil is used along with breathing devices to treat OSAHS. The disease
Shift Work Sleep Disorder (SWSD)
Shift Work Sleep Disorder (SWSD) is a condition that results from working shifts that disrupt the typical sleep/wake cycle (circadian rhythm). Approximately more than one-third of shift workers experience SWSD. Common symptoms of the disorder include insomnia and excessive sleepiness.
Other Benefits of Modalert
Studies show that modafinil can do more than just treat sleep disorders. Here are some of the drug’s other benefits.
Enhances Cognitive Function
Modafinil is a smart drug, also known as a nootropic. Researchers at the University of Oxford found modafinil significantly enhances boosts concentration and focus. Especially during complex and challenging tasks. This is one of the reasons why the drug is popular with students.
Attention Deficit Hyperactive Disorder (ADHD)
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental, mental disorder. Ongoing inattention, hyperactivity, and impulsivity are the three main characteristics of ADHD. Ritalin (methylphenidate) is the most commonly used medication to treat ADHD. Modafinil, however, is also an effective option.
Mitigates Fatigue and Lethargy
Studies show modafinil can help reduce fatigue and lethargy in healthy people. The US military uses the drug to reduce battle fatigue and enhance alertness. Astronauts use to optimize performance while fatigued, a common occurrence due to disrupted sleep cycles.
Treatment of Cocaine and Methamphetamine Dependence
Although studies are still in their infancy, results show that modafinil may help in the treatment of methamphetamine dependence as it is an atypical stimulant. Ongoing clinical trials show that modafinil may improve cognitive deficits and abstinence rates in methamphetamine-dependent individuals.
Anti-fatigue Agent for Cancer and Depression-related exhaustion
Among people with cancer and depression, fatigue is the most common symptom. Studies show modafinil is effective as an anti-fatigue agent.
Mood Booster
Modafinil increases dopamine in the human brain. As a result, studies show it can brighten one’s moods. Dopamine is fondly known as the “happy hormone.”
How Much Modalert Should You Take?
Modalert is for oral use. The drug and comes in tablet form in 100 mg, 200 mg, and 400 mg sizes. For most people, 200mg, usually taken once a day, is an optimal dose.
Modalert usually takes 30 to 60 minutes to start working. The drug may be taken with or without food. You should not take the medication with alcohol as it may cause blackouts or heighten alcohol tolerance.
Modalert Side Effects
Modalert is generally well tolerated. The drug may, however, cause side effects in certain users, the majority of which, are mild to moderate in severity.
Common side effects include the following:
- headache
- nausea
- anxiety or nervousness
- backache
- diarrhea
- difficulty Sleeping
- dizziness
- indigestion
- nausea
Severe but rare side effects include the following:
- black, tarry stools
- blurred vision or other vision changes
- chest pain
- increased thirst and urination
- mental depression
- problems with memory
- rapidly changing moods
- shortness of breath
- chills or fever
- clumsiness or unsteadiness
- confusion
- dizziness or fainting
- sore throat
- trembling or shaking
- trouble in urinating
- uncontrolled movements of the face, mouth, or tongue
- unusual bleeding, bruising, tiredness, or weakness
Can You Overdose on Modalert?
Yes, it is possible to overdose on Modalert. You may overdose on Modafinil if you consume more than 200 mg or exceed your physician’s prescribed dose. Combining Modafinil with other drugs or alcohol may also result in an overdose
Symptoms of an overdose include the following”
- agitation or excitement
- hallucinations
- slow, fast or pounding heartbeat
- increased blood pressure
- trouble with sleeping
- nausea
- diarrhea
Modalert vs. Other Amphetamines
Modafinil vs. Adderall
Modafinil and Adderall are both used in the treatment of narcolepsy. However, the former has a unique structure and is not a stimulant like Adderall.
Adderall is less preferable for a number of reasons. Not only is Modalert a much milder stimulant, but it’s also more effective. It also has a less significant risk for abuse and the development of physical dependence.
Modafinil vs. Adrafinil
Modafinil and adrafinil share many similarities as the former is a metabolite of adrafinil. However, Adrafinil is less effective and, therefore, less preferable. You also require a larger dose (600 mg-1000 mg).
Adrafinil is a prodrug. This means it only becomes pharmacologically active after its metabolized. Therefore, it takes longer to accumulate to active levels in the bloodstream.
Modalert also produces faster effects on the body. This stems from it having a longer half-life of between 10 to 15 hours. Adrafinil the other hand has a half-life of only about an hour.
Modafinil vs. Armodafinil
Armodafinil is the generic name for Nuvigil, the enantiopure compound of Modafinil. This makes both drugs similar and either can be used to treat excessive sleepiness. There is, however, one major distinction. Armodafinil is slightly stronger than Modafinil. It is, therefore, better at improving wakefulness throughout the day.
Modafinil vs Vyvanse
Vyvanse (Lisdexamfetamine) is a stimulant that works by restoring the balance of certain natural chemicals (neurotransmitters) in the brain. The drug is used in the treatment of ADHD. Compared to modafinil, Vyvanse is more potentially addictive. It also causes severe cardiac side effects. Modafinil is better tolerated.
Modafinil vs. Ritalin
Ritalin (methylphenidate) like Modalert is also a central nervous system stimulant. Both drugs are prescribed for treating attention-deficit hyperactivity disorder (ADHD). Ritalin, however, is the drug of choice for the condition, although its effects are not as enduring as Modalert’s. Modafinil is also better for stimulating wakefulness.
Is Modalert Legal?
In the US, modafinil is classified as a Schedule IV controlled substance. This groups it alongside drugs like Xanax and Valium. You need a prescription to legally obtain the drug.
In Australia, modafinil is sold under the brand name modavigil. The drug is considered a Schedule 4 medication and is illegal to use or import without a prescription.
In Canada, modafinil is a Schedule I prescription drug, meaning that a prescription is required for sale.
In most European Union countries, Modafinil is illegal to possess without a prescription. The European Medicines Agency, Union’s medical evaluatory and supervisory body, has also restricted the drug’s use to the treatment of narcolepsy.
Buying Modalert
Modalert, being a branded product, is slightly more expensive on average than the generic Modafinil. Both versions, as well as other name brands, are available online. The drug’s popularity, however, makes it ripe for knockoffs. Buying from a well-known seller is therefore crucial.
One vendor that stands out is ModafinilXL. In addition to providing a quality product, the company offers free express (with tracking) or standing shipping for orders over $150 and $80 respectively.
They accept credits cards and bitcoin and even offer full refunds on packages stuck in customs. Customers access to free Modafinil samples and returning one’s can use various discount offers.
Who Should Not Take Modalert
Anyone experiencing any of the following conditions or symptoms should not take Modalert or generic Modafinil.
- depression
- suicidal ideation
- manic or aggressive behavior
- psychotic disorder
- hypertension (high blood pressure)
- cardiac issues – e.g. heart attack, angina (chest pain, discomfort, or tightness), a low supply of oxygen-rich blood to the heart, left ventricular hypertrophy, Barlow’s syndrome or mitral valve prolapse syndrome
- severe liver disease
- severe renal impairment
Modafinil is also not recommended for people who are pregnant or elderly (over the age of 65) due to adverse side effects.
